Natchitoches is a city in and the parish seat of Natchitoches Parish, Louisiana, United States. Established in 1714 by Louis Juchereau de St. Denis as part of French Louisiana, the community was named after the Natchitoches Indian tribe. The City of Natchitoches is the oldest permanent settlement in the Louisiana Purchase. Natchitoches's sister city is Nacogdoches, Texas.

Natchitoches is the principal city of the Natchitoches Micropolitan Statistical Area, which includes all of Natchitoches Parish. It is within the Cane River National Heritage Area, significant for the contributions of the Cane River Louisiana Créoles.

The Natchitoches Meat Pie is one of the official state foods of Louisiana. It is known as a regional delicacy of North Louisiana. (See List of U.S. state foods.)

Natchitoches has long been known for its popular Christmas lighting festival which is held the first Saturday in December. The lights continue to brighten the Cane River until after New Year's Day.

Several motion pictures have been filmed in Natchitoches, including Steel Magnolias, The Man in the Moon, The Horse Soldiers, NBC's The Year Without a Santa Claus, The American Standard, as well as a Lifetime Television's series Scarlett.